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| 1st(1st leg) | ES Sétif | - | Espérance de Tunis | 0:0 (0:0) | ||
| 2nd (2nd leg) | Espérance de Tunis | - | ES Sétif | 0:1 (0:1) | ||
| 1st(1st leg): 15/04/2022 22:00 | 2nd (2nd leg): 22/04/2022 22:00 | Winner: ES Sétif | ||||
| 1st(1st leg) | Petro Atlético | - | Mamelodi Sundowns | 2:1 (2:1) | ||
| 2nd (2nd leg) | Mamelodi Sundowns | - | Petro Atlético | 1:1 (0:0) | ||
| 1st(1st leg): 16/04/2022 17:00 | 2nd (2nd leg): 23/04/2022 17:00 | Winner: Petro Atlético | ||||
| 1st(1st leg) | Al Ahly SC | - | Raja Casablanca | 2:1 (2:1) | ||
| 2nd (2nd leg) | Raja Casablanca | - | Al Ahly SC | 1:1 (1:1) | ||
| 1st(1st leg): 16/04/2022 21:00 | 2nd (2nd leg): 22/04/2022 23:00 | Winner: Al Ahly SC | ||||
| 1st(1st leg) | CR Bélouizdad | - | Wydad AC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Wydad AC | - | CR Bélouizdad | 0:0 (0:0) | ||
| 1st(1st leg): 16/04/2022 22:00 | 2nd (2nd leg): 23/04/2022 23:00 | Winner: Wydad AC | ||||
