| 1. Round | 11/09/2021 | Cerro Largo | - | Nacional | 0:3 dec. |  |
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| 2. Round | 18/09/2021 | Cerrito | - | Cerro Largo | 1:1 | ||||
| 3. Round | 25/09/2021 | Cerro Largo | - | Liverpool | 3:0 | |
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| 4. Round | 02/10/2021 | River Plate | - | Cerro Largo | 0:4 | ||||
| 5. Round | 09/10/2021 | Cerro Largo | - | Deportivo Maldonado | 1:1 | ||||
| 7. Round | 21/10/2021 | Sud América | - | Cerro Largo | 0:0 | ||||
| 8. Round | 25/10/2021 | Cerro Largo | - | Plaza Colonia | 1:0 | ||||
| 9. Round | 31/10/2021 | Fénix | - | Cerro Largo | 1:4 | |
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| 10. Round | 04/11/2021 | Cerro Largo | - | Boston River | 1:1 | ||||
| 11. Round | 08/11/2021 | Montevideo Wanderers | - | Cerro Largo | 1:2 | ||||
| 12. Round | 15/11/2021 | Cerro Largo | - | Rentistas | 1:1 | ||||
| 13. Round | 23/11/2021 | Peñarol | - | Cerro Largo | 2:2 | |
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| 14. Round | 29/11/2021 | Cerro Largo | - | Montevideo City Torque | 1:1 | ||||
| 15. Round | 05/12/2021 | Villa Española | - | Cerro Largo | 1:1 |
Uruguay