| 6. Round | 10/02/2021 | Plaza Colonia | - | Danubio | 3:0 | ||||
| 7. Round | 15/02/2021 | Danubio | - | Progreso | 0:1 | ||||
| 8. Round | 18/02/2021 | Fénix | - | Danubio | 1:1 | ||||
| 9. Round | 22/02/2021 | Danubio | - | CA Cerro | 2:1 |  |
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| 10. Round | 28/02/2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 11. Round | 07/03/2021 | Danubio | - | Liverpool | 0:1 | ||||
| 13. Round | 19/03/2021 | Boston River | - | Danubio | 1:5 | |
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| 14. Round | 23/03/2021 | Danubio | - | Deportivo Maldonado | 2:2 |  |
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| 15. Round | 29/03/2021 | Rentistas | - | Danubio | 1:0 |
Uruguay
Italy 