| 11. Round | 13/09/2021 | Aldosivi II | - | Godoy Cruz II | 1:2 |  |
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| 18. Round | 24/10/2021 | Godoy Cruz II | - | Banfield II | 2:0 | ||||
| 19. Round | 31/10/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 21. Round | 18/11/2021 | Argentinos Juniors II | - | Godoy Cruz II | 1:1 | ||||
| 22. Round | 23/11/2021 | Godoy Cruz II | - | Estudiantes II | 0:0 | ||||
| 25. Round | 11/12/2021 | Racing Club II | - | Godoy Cruz II | 2:1 |
Argentina