| 3. Round | 09/07/2022 | Oriente Petrolero | - | Royal Pari | 0:1 |  |
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| 6. Round | 27/07/2022 | Oriente Petrolero | - | CD Guabirá | 4:1 | |
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| 7. Round | 02/08/2022 | Independiente Petrolero | - | Oriente Petrolero | 1:2 | ||||
| 8. Round | 06/08/2022 | Oriente Petrolero | - | Atlético Palmaflor | 0:0 | ||||
| 9. Round | 10/08/2022 | Jorge Wilstermann | - | Oriente Petrolero | 0:1 | ||||
| 10. Round | 15/08/2022 | Oriente Petrolero | - | Real Tomayapo | 3:0 | ||||
| 11. Round | 20/08/2022 | Bolívar | - | Oriente Petrolero | 1:0 | ||||
| 12. Round | 23/08/2022 | Oriente Petrolero | - | Universitario de Vinto | 0:0 | ||||
| 14. Round | 31/08/2022 | Always Ready | - | Oriente Petrolero | 3:0 | |
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| 15. Round | 06/09/2022 | Oriente Petrolero | - | Club Aurora | 2:1 | ||||
| 16. Round | 09/09/2022 | The Strongest | - | Oriente Petrolero | 2:1 | ||||
| 23. Round | 16/10/2022 | Atlético Palmaflor | - | Oriente Petrolero | 2:2 | ||||
| 24. Round | 22/10/2022 | Oriente Petrolero | - | Jorge Wilstermann | 2:1 |
Uruguay