| 1. Round | 01/06/2021 | Albion | - | CA Cerro | 1:2 |  |
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| 2. Round | 09/06/2021 | Juventud de Las Piedras | - | Albion | 1:2 | |
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| 3. Round | 16/06/2021 | Albion | - | Defensor Sporting | 2:2 | |
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| 4. Round | 25/06/2021 | Uruguay Montevideo | - | Albion | 2:2 | |
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| 5. Round | 30/06/2021 | Albion | - | Central Español | 1:2 | ||||
| 13. Round | 22/09/2021 | Albion | - | Juventud de Las Piedras | 1:0 | ||||
| 14. Round | 30/09/2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Round | 04/10/2021 | Albion | - | Uruguay Montevideo | 1:0 | ||||
| 16. Round | 11/10/2021 | Central Español | - | Albion | 3:4 | |
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| 17. Round | 19/10/2021 | Albion | - | Rampla Juniors | 2:0 | ||||
| 18. Round | 28/10/2021 | Atenas | - | Albion | 1:2 | |
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| 19. Round | 01/11/2021 | Albion | - | Danubio | 2:1 | ||||
| 20. Round | 09/11/2021 | Racing | - | Albion | 1:1 | ||||
| 21. Round | 18/11/2021 | Albion | - | Rocha | 0:1 | ||||
| 22. Round | 24/11/2021 | Villa Teresa | - | Albion | 1:1 |
Uruguay