| 2. Round | 17/05/2021 | Rio Grande Valley FC | - | San Antonio FC | 2:1 | ||||
| 4. Round | 04/07/2021 | San Antonio FC | - | Austin Bold | 0:1 | ||||
| 4. Round | 17/07/2021 | Colorado Springs Switchbacks | - | San Antonio FC | 2:3 | ||||
| 4. Round | 01/08/2021 | Austin Bold | - | San Antonio FC | 0:3 | ||||
| 6. Round | 02/09/2021 | San Antonio FC | - | Real Monarchs SLC | 3:2 | ||||
| 6. Round | 08/09/2021 | Austin Bold | - | San Antonio FC | 2:1 |
USA
Mexico