| 22. Round | 28/09/2021 | Santa Cruz | - | Unión San Felipe | 0:1 | ||||
| 23. Round | 03/10/2021 | Deportes Iquique | - | Santa Cruz | 6:1 | ||||
| 24. Round | 08/10/2021 | Santa Cruz | - | Deportes Copiapó | 1:2 | ||||
| 26. Round | 19/10/2021 | Santa Cruz | - | Rangers | 1:0 | ||||
| 27. Round | 23/10/2021 | CD Magallanes | - | Santa Cruz | 1:1 |
Chile