| 3. Round | 29/01/2022 | Gavilanes de Matamoros | - | Mineros de Fresnillo FC | 1:0 | ||||
| 4. Round | 05/02/2022 | Mineros de Fresnillo FC | - | Mazorqueros | 1:3 |  |
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| 6. Round | 19/02/2022 | Mineros de Fresnillo FC | - | Colima FC | 0:0 |  |
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| 7. Round | 26/02/2022 | Leones Negros II | - | Mineros de Fresnillo FC | 0:0 |  |
Mexico