| 1. Round | 07/01/2023 | Deportivo Guadalajara [] | - | CF Monterrey [] | 2:5 | ||||
| 2. Round | 14/01/2023 | UANL Tigres [] | - | Deportivo Guadalajara [] | 4:1 | ||||
| 3. Round | 22/01/2023 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 2:1 | ||||
| 4. Round | 28/01/2023 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 10. Round | 11/03/2023 | CF Monterrey [] | - | Deportivo Guadalajara [] | 3:1 | ||||
| 13. Round | 01/04/2023 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:1 | ||||
| 14. Round | 08/04/2023 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 15. Round | 15/04/2023 | Santos Laguna [] | - | Deportivo Guadalajara [] | 5:3 |  |
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| 16. Round | 22/04/2023 | Deportivo Guadalajara [] | - | UANL Tigres [] | 3:2 | ||||
| 18. Round | 06/05/2023 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 4:2 |
Mexico