| 2. Round | 16/01/2021 | Deportivo Guadalajara [U17] | - | Deportivo Toluca [U17] | 1:1 |  |
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| 3. Round | 21/01/2021 | Atlético San Luis [U17] | - | Deportivo Guadalajara [U17] | 0:3 |  |
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| 4. Round | 30/01/2021 | Deportivo Guadalajara [U17] | - | FC Juárez [U17] | 4:1 | |
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| 11. Round | 14/03/2021 | Deportivo Guadalajara [U17] | - | CF América [U17] | 3:0 | ||||
| 12. Round | 20/03/2021 | CF Monterrey [U17] | - | Deportivo Guadalajara [U17] | 0:1 | ||||
| 1. Round | 27/03/2021 | Puebla FC [U17] | - | Deportivo Guadalajara [U17] | 0:0 | ||||
| 13. Round | 04/04/2021 | Deportivo Guadalajara [U17] | - | Santos Laguna [U17] | 2:0 | |
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| 14. Round | 10/04/2021 | Cruz Azul [U17] | - | Deportivo Guadalajara [U17] | 3:2 | ||||
| 15. Round | 17/04/2021 | Deportivo Guadalajara [U17] | - | Club Tijuana [U17] | 1:1 | |
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| 16. Round | 24/04/2021 | Atlas Guadalajara [U17] | - | Deportivo Guadalajara [U17] | 1:0 | ||||
| 17. Round | 01/05/2021 | Deportivo Guadalajara [U17] | - | UANL Tigres [U17] | 1:0 |
Mexico