| 1. Round | 10/01/2021 | CF América | - | Atlético San Luis | 2:1 | ||||
| 2. Round | 17/01/2021 | CF Monterrey | - | CF América | 1:0 | ||||
| 3. Round | 27/01/2021 | CF América | - | FC Juárez | 2:0 | ||||
| 4. Round | 01/02/2021 | Santos Laguna | - | CF América | 1:1 | ||||
| 5. Round | 07/02/2021 | CF América | - | Puebla FC | 1:0 | ||||
| 6. Round | 14/02/2021 | CF América | - | Gallos Blancos | 2:1 | ||||
| 8. Round | 28/02/2021 | CF América | - | CF Pachuca | 2:0 | ||||
| 9. Round | 04/03/2021 | Club Tijuana | - | CF América | 0:2 | ||||
| 10. Round | 07/03/2021 | CF América | - | Club León | 2:1 | ||||
| 11. Round | 15/03/2021 | Deportivo Guadalajara | - | CF América | 0:3 | ||||
| 12. Round | 20/03/2021 | Mazatlán FC | - | CF América | 0:1 | ||||
| 14. Round | 11/04/2021 | UANL Tigres | - | CF América | 1:3 | ||||
| 15. Round | 18/04/2021 | CF América | - | Cruz Azul | 1:1 | ||||
| 17. Round | 03/05/2021 | Pumas UNAM | - | CF América | 0:1 |
Argentina
Spain