| 1. Round | 26/07/2008 | Club San Luis | - | Monarcas Morelia | 2:2 | ||||
| 2. Round | 03/08/2008 | CF Pachuca | - | Club San Luis | 2:3 |  |
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| 6. Round | 07/08/2008 | Club San Luis | - | Cruz Azul | 2:1 | ||||
| 3. Round | 09/08/2008 | Club San Luis | - | Jaguares Chiapas | 2:0 | ||||
| 4. Round | 17/08/2008 | Atlas Guadalajara | - | Club San Luis | 0:1 | |
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| 5. Round | 23/08/2008 | Club San Luis | - | UANL Tigres | 1:0 |  |
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| 8. Round | 13/09/2008 | Club San Luis | - | CF América | 1:2 | ||||
| 9. Round | 21/09/2008 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 10. Round | 27/09/2008 | Club San Luis | - | Puebla FC | 1:1 | ||||
| 11. Round | 05/10/2008 | Indios Juárez | - | Club San Luis | 2:3 | ||||
| 12. Round | 11/10/2008 | Club San Luis | - | Deportivo Guadalajara | 0:0 | ||||
| 13. Round | 18/10/2008 | UAG Tecos | - | Club San Luis | 5:2 | ||||
| 14. Round | 25/10/2008 | Club San Luis | - | CF Monterrey | 2:0 | ||||
| 15. Round | 02/11/2008 | Club Necaxa | - | Club San Luis | 1:1 | ||||
| 16. Round | 08/11/2008 | Club San Luis | - | Santos Laguna | 2:2 | ||||
| 17. Round | 16/11/2008 | Deportivo Toluca | - | Club San Luis | 1:0 |
Mexico