| 1. Round | 15/08/2021 | 1899 Hoffenheim II [Women] | - | SV Henstedt-Ulzburg [Women] | 4:1 |  |
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| 2. Round | 29/08/2021 | RB Leipzig [Women] | - | 1899 Hoffenheim II [Women] | 2:0 | ||||
| 3. Round | 05/09/2021 | 1899 Hoffenheim II [Women] | - | MSV Duisburg [Women] | 1:0 | ||||
| 4. Round | 12/09/2021 | VfL Wolfsburg II [Women] | - | 1899 Hoffenheim II [Women] | 0:0 | ||||
| 5. Round | 03/10/2021 | FSV Gütersloh 2009 [Women] | - | 1899 Hoffenheim II [Women] | 1:1 | ||||
| 6. Round | 10/10/2021 | 1899 Hoffenheim II [Women] | - | Bayern München II [Women] | 0:1 |  |
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| 7. Round | 16/10/2021 | Eintracht Frankfurt II [Women] | - | 1899 Hoffenheim II [Women] | 4:2 | ||||
| 8. Round | 07/11/2021 | 1899 Hoffenheim II [Women] | - | SV Meppen [Women] | 0:3 | ||||
| 9. Round | 14/11/2021 | SG 99 Andernach [Women] | - | 1899 Hoffenheim II [Women] | 2:3 |
Germany