| 3. Round | 05/08/2018 | Deportivo Toluca [U20] | - | Deportivo Guadalajara [U20] | 2:2 | ||||
| 4. Round | 12/08/2018 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 5. Round | 17/08/2018 | CD Veracruz [U20] | - | Deportivo Guadalajara [U20] | 0:2 | ||||
| 10. Round | 23/09/2018 | Deportivo Guadalajara [U20] | - | Gallos Blancos [U20] | 5:1 | ||||
| 11. Round | 30/09/2018 | CF América [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 12. Round | 05/10/2018 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 2:0 | ||||
| 16. Round | 10/11/2018 | Club León [U20] | - | Deportivo Guadalajara [U20] | 2:0 | ||||
| 17. Round | 24/11/2018 | Deportivo Guadalajara [U20] | - | UANL Tigres [U20] | 3:2 |  |
Mexico