| 1. Round | 10/07/2021 | FK Neftekhimik | - | Olimp-Dolgoprudny | 1:0 |  |
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| 3. Round | 24/07/2021 | Volgar Astrakhan | - | FK Neftekhimik | 1:0 | ||||
| 6. Round | 14/08/2021 | FK Neftekhimik | - | Fakel Voronezh | 3:0 | ||||
| 9. Round | 05/09/2021 | Akron Tolyatti | - | FK Neftekhimik | 1:3 | ||||
| 10. Round | 11/09/2021 | Veles Moskva | - | FK Neftekhimik | 1:2 | ||||
| 11. Round | 15/09/2021 | FK Neftekhimik | - | Rotor Volgograd | 1:3 | ||||
| 17. Round | 13/10/2021 | FK Neftekhimik | - | Spartak Moskva 2 | 5:0 | ||||
| 18. Round | 17/10/2021 | Alania Vladikavkaz | - | FK Neftekhimik | 2:3 | ||||
| 21. Round | 06/11/2021 | FK Neftekhimik | - | Volgar Astrakhan | 0:1 | |
Russia