| 2. Round | 14/08/2022 | AFC Ajax | - | FC Groningen | 6:1 | ||||
| 5. Round | 04/09/2022 | FC Groningen | - | Vitesse | 0:1 | ||||
| 6. Round | 11/09/2022 | SC Cambuur | - | FC Groningen | 0:1 | ||||
| 7. Round | 17/09/2022 | Sparta Rotterdam | - | FC Groningen | 2:1 | ||||
| 8. Round | 01/10/2022 | FC Groningen | - | AZ Alkmaar | 1:4 | ||||
| 15. Round | 08/01/2023 | SBV Excelsior | - | FC Groningen | 1:0 |  |
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| 16. Round | 15/01/2023 | FC Groningen | - | Feyenoord | 0:3 | ||||
| 17. Round | 22/01/2023 | sc Heerenveen | - | FC Groningen | 3:1 | |
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| 18. Round | 26/01/2023 | FC Groningen | - | SC Cambuur | 0:1 | ||||
| 19. Round | 29/01/2023 | FC Volendam | - | FC Groningen | 3:2 | ||||
| 22. Round | 18/02/2023 | FC Groningen | - | FC Emmen | 1:1 | ||||
| 23. Round | 25/02/2023 | FC Groningen | - | SBV Excelsior | 3:0 |  |
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| 24. Round | 04/03/2023 | Feyenoord | - | FC Groningen | 1:0 | |
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| 25. Round | 11/03/2023 | AZ Alkmaar | - | FC Groningen | 1:0 | |
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| 26. Round | 19/03/2023 | FC Groningen | - | sc Heerenveen | 0:2 | ||||
| 27. Round | 02/04/2023 | Fortuna Sittard | - | FC Groningen | 3:1 | ||||
| 28. Round | 07/04/2023 | FC Groningen | - | FC Utrecht | 1:2 |
Netherlands