1. Round | 25/07/2021 | Spartak Trnava | - | FK Pohronie | 2:0 | ||||
4. Round | 14/08/2021 | FK Pohronie | - | ŠKF Sereď | 1:1 | ||||
5. Round | 20/08/2021 | Zlaté Moravce | - | FK Pohronie | 1:0 | ||||
6. Round | 27/08/2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | ||||
9. Round | 24/09/2021 | FK Pohronie | - | AS Trenčín | 2:2 | ||||
10. Round | 03/10/2021 | Slovan Bratislava | - | FK Pohronie | 5:1 | ||||
11. Round | 16/10/2021 | FK Pohronie | - | MFK Ružomberok | 2:2 | ||||
12. Round | 23/10/2021 | FK Pohronie | - | Spartak Trnava | 0:2 | ||||
13. Round | 30/10/2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 | ||||
14. Round | 06/11/2021 | FK Pohronie | - | MŠK Žilina | 1:2 | ||||
15. Round | 20/11/2021 | ŠKF Sereď | - | FK Pohronie | 3:1 | ||||
16. Round | 27/11/2021 | FK Pohronie | - | Zlaté Moravce | 0:2 |