| 22. Round | 12/02/2022 | FC Groningen | - | Fortuna Sittard | 0:1 | ||||
| 25. Round | 06/03/2022 | Fortuna Sittard | - | PEC Zwolle | 0:1 | ||||
| 26. Round | 13/03/2022 | Fortuna Sittard | - | Willem II | 1:0 | ||||
| 27. Round | 20/03/2022 | PSV Eindhoven | - | Fortuna Sittard | 5:0 | ||||
| 28. Round | 03/04/2022 | Fortuna Sittard | - | Heracles Almelo | 0:2 | ||||
| 29. Round | 09/04/2022 | FC Utrecht | - | Fortuna Sittard | 1:1 | ||||
| 32. Round | 07/05/2022 | FC Twente | - | Fortuna Sittard | 1:2 | ||||
| 33. Round | 11/05/2022 | Fortuna Sittard | - | Vitesse | 1:2 | ||||
| 34. Round | 15/05/2022 | NEC Nijmegen | - | Fortuna Sittard | 0:1 |  |
Portugal