| 1. Round | 26/03/2022 | El Nacional [Women] | - | Guayaquil City [Women] | 2:0 | ||||
| 2. Round | 01/04/2022 | Universidad Católica [Women] | - | Guayaquil City [Women] | 5:0 | ||||
| 3. Round | 15/04/2022 | Guayaquil City [Women] | - | LDU Quito [Women] | 1:4 | ||||
| 8. Round | 22/05/2022 | Guayaquil City [Women] | - | El Nacional [Women] | 1:2 | ||||
| 9. Round | 28/05/2022 | Guayaquil City [Women] | - | Universidad Católica [Women] | 1:3 | ||||
| 10. Round | 03/06/2022 | LDU Quito [Women] | - | Guayaquil City [Women] | 8:0 | ||||
| 11. Round | 11/06/2022 | Guayaquil City [Women] | - | Técnico Universitario [Women] | 1:2 | ||||
| 12. Round | 23/07/2022 | Barcelona [Women] | - | Guayaquil City [Women] | 6:1 | ||||
| 13. Round | 30/07/2022 | Guayaquil City [Women] | - | UPS Carneras [Women] | 4:0 | ||||
| 14. Round | 05/08/2022 | Deportivo Ibarra [Women] | - | Guayaquil City [Women] | 8:0 |
Ecuador