| 1. Round | 24/07/2021 | Havre AC | - | EA Guingamp | 0:0 | ||||
| 5. Round | 23/08/2021 | AJ Auxerre | - | EA Guingamp | 1:2 | ||||
| 6. Round | 28/08/2021 | EA Guingamp | - | AC Ajaccio | 1:1 | ||||
| 7. Round | 11/09/2021 | Paris FC | - | EA Guingamp | 0:1 | ||||
| 8. Round | 18/09/2021 | Chamois Niortais | - | EA Guingamp | 2:0 | ||||
| 13. Round | 23/10/2021 | EA Guingamp | - | Nîmes Olympique | 3:1 | ||||
| 14. Round | 30/10/2021 | Toulouse FC | - | EA Guingamp | 2:2 | ||||
| 15. Round | 06/11/2021 | EA Guingamp | - | SC Bastia | 2:3 | ||||
| 16. Round | 20/11/2021 | Pau FC | - | EA Guingamp | 2:0 | ||||
| 17. Round | 03/12/2021 | EA Guingamp | - | Dijon FCO | 3:2 | ||||
| 18. Round | 11/12/2021 | SM Caen | - | EA Guingamp | 2:0 |  |
|||
| 19. Round | 21/12/2021 | EA Guingamp | - | USL Dunkerque | 2:1 |
Belgium