| 10. Round | 28/10/2018 | Reboceros de La Piedad | - | Tuxtla FC | 0:3 | ||||
| 11. Round | 03/11/2018 | Tuxtla FC | - | Inter Playa | 1:1 | ||||
| 12. Round | 10/11/2018 | Yalmakan FC | - | Tuxtla FC | 2:3 | ||||
| 13. Round | 17/11/2018 | Tuxtla FC | - | CF América II | 1:1 | ||||
| 14. Round | 24/11/2018 | Tuxtla FC | - | Cruz Azul Hidalgo | 2:0 | ||||
| 15. Round | 30/11/2018 | Pumas UNAM II | - | Tuxtla FC | 2:1 | ||||
| 27. Round | 30/03/2019 | Tuxtla FC | - | Yalmakan FC | 4:1 | ||||
| 28. Round | 05/04/2019 | CF América II | - | Tuxtla FC | 1:1 |
Mexico