| 1. Round | 12/09/2021 | Volos NFC | - | Lamia | 2:1 | ||||
| 2. Round | 19/09/2021 | Lamia | - | Olympiakos Piraeus | 1:2 | ||||
| 3. Round | 22/09/2021 | AEK Athen | - | Lamia | 1:0 | ||||
| 4. Round | 26/09/2021 | Lamia | - | Panetolikos | 2:2 | ||||
| 5. Round | 03/10/2021 | Ionikos Nikea | - | Lamia | 1:2 | ||||
| 6. Round | 18/10/2021 | Lamia | - | Aris Saloniki | 0:1 | ||||
| 7. Round | 24/10/2021 | OFI Heraklion | - | Lamia | 0:0 | ||||
| 22. Round | 23/02/2022 | Lamia | - | Asteras Tripolis | 0:2 |
Czech Republic