| 15. Round | 05/10/2021 | Central Español | - | Defensor Sporting | 1:0 |  |
|||
| 19. Round | 02/11/2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 | ||||
| 20. Round | 10/11/2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | |
|||
| 21. Round | 18/11/2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Round | 24/11/2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay