| 2. Round | 25/10/2020 | Guaireña FC | - | Club Olimpia | 2:1 | ||||
| 3. Round | 02/11/2020 | Sol de América | - | Guaireña FC | 1:1 | ||||
| 4. Round | 07/11/2020 | Guaireña FC | - | Cerro Porteño | 1:1 | ||||
| 5. Round | 10/11/2020 | River Plate | - | Guaireña FC | 1:2 | ||||
| 6. Round | 14/11/2020 | Guaireña FC | - | General Díaz | 1:1 | ||||
| 8. Round | 27/11/2020 | Guaireña FC | - | San Lorenzo | 2:2 |  |
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| 9. Round | 06/12/2020 | 12 de Octubre de Itauguá | - | Guaireña FC | 3:0 | ||||
| 10. Round | 11/12/2020 | Guaireña FC | - | Sportivo Luqueño | 1:0 | ||||
| 11. Round | 19/12/2020 | Guaraní | - | Guaireña FC | 1:0 |
Paraguay