| 1. Round | 16/07/2021 | River Plate II | - | Colón de Santa Fe II | 1:2 | ||||
| 2. Round | 23/07/2021 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 7. Round | 19/08/2021 | Gimnasia de La Plata II | - | River Plate II | 3:1 | ||||
| 8. Round | 23/08/2021 | River Plate II | - | Aldosivi II | 3:0 | ||||
| 9. Round | 31/08/2021 | Sarmiento de Junín II | - | River Plate II | 3:1 | ||||
| 10. Round | 06/09/2021 | River Plate II | - | Independiente II | 4:0 | ||||
| 11. Round | 10/09/2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Round | 17/09/2021 | River Plate II | - | Arsenal de Sarandí II | 0:1 | ||||
| 13. Round | 24/09/2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | ||||
| 14. Round | 01/10/2021 | River Plate II | - | Boca Juniors II | 0:3 | ||||
| 16. Round | 15/10/2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Round | 20/10/2021 | Talleres de Córdoba II | - | River Plate II | 1:0 | ||||
| 19. Round | 31/10/2021 | Estudiantes II | - | River Plate II | 0:0 | ||||
| 20. Round | 05/11/2021 | River Plate II | - | Patronato de Paraná II | 2:0 |
Argentina