| 4. Round | 13/09/2021 | Getafe CF | - | Elche CF | 0:1 |  |
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| 5. Round | 18/09/2021 | Elche CF | - | Levante UD | 1:1 | |
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| 6. Round | 22/09/2021 | Villarreal CF | - | Elche CF | 4:1 | ||||
| 7. Round | 26/09/2021 | Real Sociedad | - | Elche CF | 1:0 | ||||
| 8. Round | 03/10/2021 | Elche CF | - | RC Celta | 1:0 | ||||
| 9. Round | 17/10/2021 | Rayo Vallecano | - | Elche CF | 2:1 | ||||
| 10. Round | 23/10/2021 | Elche CF | - | Espanyol Barcelona | 2:2 | ||||
| 11. Round | 26/10/2021 | CD Alavés | - | Elche CF | 1:0 | ||||
| 12. Round | 30/10/2021 | Elche CF | - | Real Madrid | 1:2 | ||||
| 13. Round | 07/11/2021 | RCD Mallorca | - | Elche CF | 2:2 | ||||
| 14. Round | 21/11/2021 | Elche CF | - | Real Betis | 0:3 | ||||
| 15. Round | 29/11/2021 | CA Osasuna | - | Elche CF | 1:1 | ||||
| 16. Round | 05/12/2021 | Elche CF | - | Cádiz CF | 3:1 | ||||
| 17. Round | 11/12/2021 | Valencia CF | - | Elche CF | 2:1 | ||||
| 18. Round | 18/12/2021 | FC Barcelona | - | Elche CF | 3:2 | ||||
| 20. Round | 10/01/2022 | Espanyol Barcelona | - | Elche CF | 1:2 | ||||
| 21. Round | 16/01/2022 | Elche CF | - | Villarreal CF | 1:0 | ||||
| 22. Round | 23/01/2022 | Real Madrid | - | Elche CF | 2:2 |
Spain
