| 8. Round | 21/08/2021 | Mannucci | - | FBC Melgar | 1:2 | ||||
| 9. Round | 28/08/2021 | Alianza Atlético | - | Mannucci | 2:0 |  |
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| 10. Round | 12/09/2021 | Mannucci | - | Universidad Técnica | 1:3 | |
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| 11. Round | 18/09/2021 | Mannucci | - | Alianza Universidad | 1:1 |  |
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| 13. Round | 25/09/2021 | Mannucci | - | Cienciano | 1:3 | ||||
| 14. Round | 01/10/2021 | Ayacucho FC | - | Mannucci | 3:2 | ||||
| 15. Round | 16/10/2021 | Mannucci | - | Alianza Lima | 0:1 | |
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| 17. Round | 30/10/2021 | Mannucci | - | Academia Cantolao | 1:0 |
Uruguay