| 1. Round | 30/04/2022 | Central Español | - | La Luz | 3:2 |  |
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| 2. Round | 06/05/2022 | Atenas | - | Central Español | 1:1 | ||||
| 3. Round | 14/05/2022 | Central Español | - | CA Cerro | 1:2 | ||||
| 4. Round | 21/05/2022 | Sud América | - | Central Español | 2:1 | ||||
| 5. Round | 25/05/2022 | Uruguay Montevideo | - | Central Español | 2:0 | ||||
| 6. Round | 30/05/2022 | Central Español | - | Miramar Misiones | 1:1 | ||||
| 9. Round | 19/06/2022 | Racing | - | Central Español | 1:0 | ||||
| 10. Round | 23/06/2022 | Central Español | - | Rampla Juniors | 2:0 |  |
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| 11. Round | 25/06/2022 | Progreso | - | Central Español | 1:1 | ||||
| 12. Round | 24/07/2022 | La Luz | - | Central Español | 0:0 | ||||
| 13. Round | 30/07/2022 | Central Español | - | Atenas | 3:2 | ||||
| 14. Round | 05/08/2022 | CA Cerro | - | Central Español | 2:0 | ||||
| 15. Round | 13/08/2022 | Central Español | - | Sud América | 1:1 | |
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| 18. Round | 28/08/2022 | Central Español | - | Villa Española | 2:0 | ||||
| 20. Round | 11/09/2022 | Central Español | - | Racing | 1:2 | ||||
| 21. Round | 18/09/2022 | Rampla Juniors | - | Central Español | 3:0 |
Uruguay