| 1. Round | 02/08/2022 | Peñarol | - | Fénix | 0:1 | ||||
| 2. Round | 07/08/2022 | Defensor Sporting | - | Peñarol | 2:3 |  |
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| 3. Round | 13/08/2022 | Peñarol | - | Albion | 2:0 | ||||
| 6. Round | 22/08/2022 | Deportivo Maldonado | - | Peñarol | 1:1 | ||||
| 5. Round | 28/08/2022 | Peñarol | - | Danubio | 1:1 | |
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| 4. Round | 04/09/2022 | Nacional | - | Peñarol | 3:1 | ||||
| 7. Round | 11/09/2022 | Peñarol | - | Rentistas | 2:2 |  |
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| 8. Round | 15/09/2022 | Liverpool | - | Peñarol | 0:1 | ||||
| 11. Round | 02/10/2022 | Montevideo Wanderers | - | Peñarol | 0:2 | ||||
| 12. Round | 09/10/2022 | Peñarol | - | Plaza Colonia | 0:1 | ||||
| 13. Round | 12/10/2022 | Boston River | - | Peñarol | 2:1 | ||||
| 14. Round | 16/10/2022 | Peñarol | - | River Plate | 1:1 | ||||
| 15. Round | 22/10/2022 | Cerro Largo | - | Peñarol | 0:2 |
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