| 1. Round | 27/08/2005 | Skoda Xanthi | - | PAOK Saloniki | 1:0 | ||||
| 2. Round | 11/09/2005 | OFI Heraklion | - | Skoda Xanthi | 1:1 |  |
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| 3. Round | 18/09/2005 | Skoda Xanthi | - | Apollon Kalamarias | 2:0 |  |
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| 4. Round | 25/09/2005 | Skoda Xanthi | - | Levadiakos | 1:0 | |
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| 5. Round | 03/10/2005 | Atromitos | - | Skoda Xanthi | 0:1 | ||||
| 6. Round | 17/10/2005 | Skoda Xanthi | - | Iraklis Saloniki | 4:1 | |
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| 7. Round | 23/10/2005 | AO Egaleo | - | Skoda Xanthi | 3:2 | |
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| 8. Round | 30/10/2005 | Skoda Xanthi | - | AE Lárissa | 1:0 | |
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| 9. Round | 06/11/2005 | Olympiakos Piraeus | - | Skoda Xanthi | 2:0 | |
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| 10. Round | 19/11/2005 | Skoda Xanthi | - | Ionikos Nikea | 1:1 | |
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| 11. Round | 26/11/2005 | Panathinaikos | - | Skoda Xanthi | 2:1 |
Brazil