| 1. Round | 24/07/2021 | CF Pachuca [U18] | - | Club León [U18] | 5:1 | ||||
| 2. Round | 31/07/2021 | Club León [U18] | - | Club Tijuana [U18] | 2:1 | ||||
| 4. Round | 14/08/2021 | Club León [U18] | - | Mazatlán FC [U18] | 1:1 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U18] | - | Club León [U18] | 1:1 | ||||
| 9. Round | 18/09/2021 | Club León [U18] | - | FC Juárez [U18] | 2:1 | ||||
| 13. Round | 16/10/2021 | CF Monterrey [U18] | - | Club León [U18] | 0:1 | ||||
| 14. Round | 20/10/2021 | Club León [U18] | - | Pumas UNAM [U18] | 2:1 | ||||
| 15. Round | 23/10/2021 | Puebla FC [U18] | - | Club León [U18] | 2:1 |  |
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| 17. Round | 06/11/2021 | Club León [U18] | - | Club Necaxa [U18] | 3:2 |
Mexico