| 2. Round | 11/08/2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
| 9. Round | 15/09/2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
| 10. Round | 19/09/2021 | Lobos UPNFM | - | Motagua | 2:2 | ||||
| 11. Round | 26/09/2021 | Platense | - | Lobos UPNFM | 2:3 | ||||
| 13. Round | 10/10/2021 | Lobos UPNFM | - | Vida | 0:0 | ||||
| 14. Round | 17/10/2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
| 15. Round | 24/10/2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
| 17. Round | 31/10/2021 | Olimpia | - | Lobos UPNFM | 2:1 |
Honduras