| 1. Round | 11/01/2025 | Mazatlán FC | - | FC Juárez | 1:1 | ||||
| 2. Round | 18/01/2025 | UANL Tigres | - | Mazatlán FC | 2:1 | ||||
| 3. Round | 25/01/2025 | Mazatlán FC | - | Deportivo Toluca | 2:1 |  |
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| 4. Round | 29/01/2025 | Puebla FC | - | Mazatlán FC | 0:1 |  |
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| 5. Round | 01/02/2025 | Mazatlán FC | - | Club León | 1:2 | ||||
| 7. Round | 15/02/2025 | Mazatlán FC | - | Santos Laguna | 1:1 | ||||
| 12. Round | 15/03/2025 | Gallos Blancos | - | Mazatlán FC | 1:0 | ||||
| 13. Round | 29/03/2025 | Mazatlán FC | - | Atlas Guadalajara | 3:2 | |
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| 14. Round | 06/04/2025 | Atlético San Luis | - | Mazatlán FC | 2:1 | ||||
| 15. Round | 12/04/2025 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | |
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| 16. Round | 17/04/2025 | Mazatlán FC | - | Club Tijuana | 0:2 | ||||
| 17. Round | 20/04/2025 | CF América | - | Mazatlán FC | 5:0 |
Paraguay