| 13. Round | 23/01/2021 | Saltillo FC | - | Mazorqueros | 3:2 | ||||
| 14. Round | 29/01/2021 | Atlético San Luis II | - | Saltillo FC | 2:0 | ||||
| 17. Round | 20/02/2021 | Saltillo FC | - | Tuzos de la UAZ | 2:3 |  |
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| 18. Round | 06/03/2021 | Alacranes de Durango | - | Saltillo FC | 3:1 | ||||
| 19. Round | 13/03/2021 | Saltillo FC | - | Cimarrones de Sonora II | 1:0 | ||||
| 20. Round | 20/03/2021 | Saltillo FC | - | Colima FC | 0:1 | ||||
| 21. Round | 03/04/2021 | Leones Negros II | - | Saltillo FC | 3:0 | ||||
| 22. Round | 10/04/2021 | Saltillo FC | - | Tecos Fútbol Club | 2:2 |
Mexico