| 3. Round | 07/08/2021 | Puebla FC [U16] | - | CF América [U16] | 3:1 | ||||
| 4. Round | 14/08/2021 | CF América [U16] | - | CF Pachuca [U16] | 0:1 | ||||
| 6. Round | 28/08/2021 | CF América [U16] | - | FC Juárez [U16] | 3:0 | ||||
| 7. Round | 04/09/2021 | Club Tijuana [U16] | - | CF América [U16] | 2:1 | ||||
| 8. Round | 11/09/2021 | Deportivo Toluca [U16] | - | CF América [U16] | 1:0 | ||||
| 9. Round | 18/09/2021 | CF América [U16] | - | Cruz Azul [U16] | 1:2 | ||||
| 10. Round | 25/09/2021 | Gallos Blancos [U16] | - | CF América [U16] | 1:2 | ||||
| 13. Round | 16/10/2021 | CF América [U16] | - | Club Tijuana [U16] | 4:2 | ||||
| 11. Round | 20/10/2021 | CF América [U16] | - | Pumas UNAM [U16] | 1:2 | ||||
| 14. Round | 23/10/2021 | Cruz Azul [U16] | - | CF América [U16] | 2:2 | ||||
| 15. Round | 30/10/2021 | CF América [U16] | - | Deportivo Toluca [U16] | 0:3 | ||||
| 16. Round | 06/11/2021 | CF Pachuca [U16] | - | CF América [U16] | 3:1 | ||||
| 18. Round | 20/11/2021 | FC Juárez [U16] | - | CF América [U16] | 2:0 |
Mexico