| 2. Round | 27/09/2021 | Saltillo FC | - | Alacranes de Durango | 1:1 | ||||
| 3. Round | 02/10/2021 | Cimarrones de Sonora II | - | Saltillo FC | 2:2 | ||||
| 5. Round | 13/10/2021 | Saltillo FC | - | Tritones Vallarta | 2:0 |  |
|||
| 6. Round | 16/10/2021 | Catedráticos Elite | - | Saltillo FC | 1:0 | ||||
| 7. Round | 23/10/2021 | Saltillo FC | - | Gavilanes de Matamoros | 3:1 | ||||
| 8. Round | 30/10/2021 | Mazorqueros | - | Saltillo FC | 1:2 | ||||
| 9. Round | 06/11/2021 | Saltillo FC | - | Tecos Fútbol Club | 3:1 | ||||
| 10. Round | 11/11/2021 | Colima FC | - | Saltillo FC | 1:2 | |
|||
| 11. Round | 13/11/2021 | Saltillo FC | - | Leones Negros II | 3:1 | ||||
| 12. Round | 20/11/2021 | Coras de Nayarit | - | Saltillo FC | 0:1 | ||||
| 13. Round | 27/11/2021 | Saltillo FC | - | Mineros de Fresnillo FC | 4:2 | |
Colombia