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| 25/09/2021 | 01:00 | Tecos Fútbol Club | - | Colima FC | 1:1 (1:1) | |
| 16:00 | Cimarrones de Sonora II | - | Correcaminos UAT II | 3:0 (2:0) | ||
| 22:00 | Catedráticos Elite | - | Mineros de Fresnillo FC | 3:1 (3:1) | ||
| 22:00 | Tritones Vallarta | - | Tuzos de la UAZ | 4:2 (2:0) | ||
| 23:00 | Gavilanes de Matamoros | - | Coras de Nayarit | 0:0 (0:0) | ||
| 23:00 | Mazorqueros | - | Leones Negros II | 3:0 (2:0) | ||
| 27/09/2021 | 22:30 | Saltillo FC | - | Alacranes de Durango | 1:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Mazorqueros | 2 | 2 | 0 | 0 | 5:1 | 4 | 12 |
| 2 |
|
Tritones Vallarta | 2 | 2 | 0 | 0 | 5:2 | 3 | 7 |
| 3 |
|
Coras de Nayarit | 2 | 0 | 2 | 0 | 2:2 | 0 | 6 |
| 4 |
|
Alacranes de Durango | 2 | 1 | 1 | 0 | 3:2 | 1 | 5 |
| 5 |
|
Gavilanes de Matamoros | 2 | 0 | 2 | 0 | 2:2 | 0 | 5 |
| 6 |
|
Catedráticos Elite | 2 | 1 | 1 | 0 | 5:3 | 2 | 4 |
| 7 |
|
Cimarrones de Sonora II | 2 | 1 | 0 | 1 | 4:2 | 2 | 3 |
| 8 |
|
Saltillo FC | 2 | 0 | 2 | 0 | 2:2 | 0 | 3 |
| 9 |
|
Correcaminos UAT II | 2 | 1 | 0 | 1 | 2:4 | -2 | 3 |
| 10 |
|
Leones Negros II | 2 | 0 | 1 | 1 | 2:5 | -3 | 3 |
| 11 |
|
Tecos Fútbol Club | 2 | 0 | 1 | 1 | 2:3 | -1 | 2 |
| 12 |
|
Tuzos de la UAZ | 2 | 0 | 1 | 1 | 3:5 | -2 | 2 |
| 13 |
|
Mineros de Fresnillo FC | 2 | 0 | 0 | 2 | 1:4 | -3 | 2 |
| 14 |
|
Colima FC | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 |
| Playoffs |
