| 1. Round | 03/02/2018 | Guaraní | - | Sol de América | 6:2 |  |
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| 2. Round | 10/02/2018 | Libertad | - | Guaraní | 2:0 | ||||
| 4. Round | 26/02/2018 | Club Olimpia | - | Guaraní | 5:2 | ||||
| 5. Round | 05/03/2018 | Guaraní | - | Independiente CG | 0:1 | ||||
| 6. Round | 11/03/2018 | General Díaz | - | Guaraní | 0:3 | ||||
| 9. Round | 24/03/2018 | Deportivo Santaní | - | Guaraní | 2:0 |  |
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| 13. Round | 22/04/2018 | Guaraní | - | Libertad | 0:2 | ||||
| 16. Round | 08/05/2018 | Independiente CG | - | Guaraní | 2:1 | ||||
| 19. Round | 26/05/2018 | Club Nacional | - | Guaraní | 3:0 |
Paraguay
Spain