| 1. Round | 06/02/2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
| 3. Round | 15/02/2021 | Sol de América | - | River Plate | 1:1 | ||||
| 4. Round | 19/02/2021 | River Plate | - | Sportivo Luqueño | 1:0 | ||||
| 6. Round | 05/03/2021 | River Plate | - | Guaireña FC | 0:1 | ||||
| 7. Round | 09/03/2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
| 8. Round | 13/03/2021 | River Plate | - | Club Nacional | 0:0 | ||||
| 9. Round | 21/03/2021 | Club Olimpia | - | River Plate | 5:1 | ||||
| 10. Round | 01/04/2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
| 11. Round | 13/04/2021 | Guaraní | - | River Plate | 2:0 |
Paraguay
Spain