| 1. Round | 18/07/2018 | Guaraní | - | Deportivo Capiatá | 1:0 |  |
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| 2. Round | 22/07/2018 | Cerro Porteño | - | Guaraní | 1:1 | |
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| 3. Round | 28/07/2018 | Guaraní | - | Independiente CG | 0:0 | ||||
| 4. Round | 05/08/2018 | Guaraní | - | Club Nacional | 1:1 | |
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| 5. Round | 12/08/2018 | Libertad | - | Guaraní | 3:0 | |
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| 6. Round | 19/08/2018 | Guaraní | - | Sol de América | 2:1 | |
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| 9. Round | 09/09/2018 | General Díaz | - | Guaraní | 3:1 | ||||
| 10. Round | 15/09/2018 | Guaraní | - | Deportivo Santaní | 1:0 | ||||
| 11. Round | 22/09/2018 | Sportivo Luqueño | - | Guaraní | 0:3 |
Paraguay