| 1. Round | 23/01/2019 | Guaraní | - | Cerro Porteño | 0:1 | ||||
| 2. Round | 26/01/2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 3. Round | 01/02/2019 | Guaraní | - | Libertad | 3:1 |  |
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| 4. Round | 06/02/2019 | San Lorenzo | - | Guaraní | 1:3 | ||||
| 5. Round | 11/02/2019 | Guaraní | - | Deportivo Capiatá | 1:2 | ||||
| 6. Round | 15/02/2019 | Sportivo Luqueño | - | Guaraní | 0:2 | ||||
| 7. Round | 23/02/2019 | Guaraní | - | General Díaz | 1:1 |  |
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| 8. Round | 28/02/2019 | Deportivo Santaní | - | Guaraní | 1:1 | ||||
| 10. Round | 10/03/2019 | Sol de América | - | Guaraní | 1:4 | ||||
| 11. Round | 17/03/2019 | Guaraní | - | Club Olimpia | 1:5 | ||||
| 13. Round | 31/03/2019 | Guaraní | - | Club Nacional | 2:2 | ||||
| 15. Round | 09/04/2019 | Guaraní | - | San Lorenzo | 4:1 | ||||
| 16. Round | 12/04/2019 | Deportivo Capiatá | - | Guaraní | 0:1 | ||||
| 14. Round | 18/04/2019 | Libertad | - | Guaraní | 1:1 | |
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| 17. Round | 23/04/2019 | Guaraní | - | Sportivo Luqueño | 2:2 | |
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| 18. Round | 27/04/2019 | General Díaz | - | Guaraní | 1:1 | ||||
| 20. Round | 07/05/2019 | River Plate | - | Guaraní | 0:1 | |
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| 21. Round | 11/05/2019 | Guaraní | - | Sol de América | 3:1 | ||||
| 22. Round | 18/05/2019 | Club Olimpia | - | Guaraní | 2:0 |
Paraguay