| 2. Round | 25/09/2020 | Mazorqueros | - | Saltillo FC | 1:1 | ||||
| 6. Round | 25/10/2020 | Tuzos de la UAZ | - | Saltillo FC | 0:0 | ||||
| 5. Round | 31/10/2020 | Saltillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 8. Round | 13/11/2020 | Cimarrones de Sonora II | - | Saltillo FC | 0:2 | ||||
| 7. Round | 17/11/2020 | Saltillo FC | - | Alacranes de Durango | 1:2 | ||||
| 9. Round | 21/11/2020 | Colima FC | - | Saltillo FC | 3:0 |  |
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| 10. Round | 05/12/2020 | Saltillo FC | - | Leones Negros II | 2:0 | ||||
| 11. Round | 10/12/2020 | Tecos Fútbol Club | - | Saltillo FC | 0:0 | ||||
| 12. Round | 15/01/2021 | Mineros de Fresnillo FC | - | Saltillo FC | 2:2 | ||||
| 13. Round | 23/01/2021 | Saltillo FC | - | Mazorqueros | 3:2 | ||||
| 14. Round | 29/01/2021 | Atlético San Luis II | - | Saltillo FC | 2:0 | ||||
| 16. Round | 12/02/2021 | Gavilanes de Matamoros | - | Saltillo FC | 2:1 |  |
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| 19. Round | 13/03/2021 | Saltillo FC | - | Cimarrones de Sonora II | 1:0 | ||||
| 21. Round | 03/04/2021 | Leones Negros II | - | Saltillo FC | 3:0 | ||||
| 22. Round | 10/04/2021 | Saltillo FC | - | Tecos Fútbol Club | 2:2 |  |
Mexico