| 6. Round | 19/02/2022 | Saltillo FC | - | Catedráticos Elite | 3:0 | ||||
| 8. Round | 05/03/2022 | Saltillo FC | - | Mazorqueros | 1:5 | ||||
| 9. Round | 12/03/2022 | Tecos Fútbol Club | - | Saltillo FC | 1:2 | ||||
| 10. Round | 19/03/2022 | Saltillo FC | - | Colima FC | 2:1 | ||||
| 12. Round | 02/04/2022 | Saltillo FC | - | Coras de Nayarit | 2:1 | ||||
| 13. Round | 09/04/2022 | Mineros de Fresnillo FC | - | Saltillo FC | 0:5 |  |
Mexico