| 2. Round | 15/01/2022 | Deportivo Toluca [U16] | - | Club Necaxa [U16] | 7:1 |  |
|||
| 3. Round | 22/01/2022 | Gallos Blancos [U16] | - | Deportivo Toluca [U16] | 2:2 | ||||
| 4. Round | 29/01/2022 | Deportivo Toluca [U16] | - | Pumas UNAM [U16] | 2:0 | ||||
| 5. Round | 05/02/2022 | Deportivo Toluca [U16] | - | Cruz Azul [U16] | 0:4 | ||||
| 6. Round | 12/02/2022 | Puebla FC [U16] | - | Deportivo Toluca [U16] | 1:2 | ||||
| 1. Round | 15/02/2022 | FC Juárez [U16] | - | Deportivo Toluca [U16] | 3:1 | ||||
| 8. Round | 26/02/2022 | CF América [U16] | - | Deportivo Toluca [U16] | 0:4 |  |
|||
| 9. Round | 05/03/2022 | Deportivo Toluca [U16] | - | CF Pachuca [U16] | 1:1 | |
|||
| 10. Round | 12/03/2022 | Deportivo Toluca [U16] | - | Puebla FC [U16] | 3:4 | ||||
| 11. Round | 19/03/2022 | Club Necaxa [U16] | - | Deportivo Toluca [U16] | 1:0 | ||||
| 13. Round | 02/04/2022 | Cruz Azul [U16] | - | Deportivo Toluca [U16] | 0:1 |
Mexico