| 3. Round | 05/08/2023 | Atlético San Luis [] | - | Santos Laguna [] | 0:2 | ||||
| 5. Round | 19/08/2023 | UANL Tigres [] | - | Santos Laguna [] | 2:1 | ||||
| 7. Round | 03/09/2023 | Santos Laguna [] | - | Club Tijuana [] | 2:3 | ||||
| 8. Round | 09/09/2023 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:1 | ||||
| 9. Round | 16/09/2023 | Santos Laguna [] | - | CF Monterrey [] | 4:2 | ||||
| 10. Round | 23/09/2023 | Club León [] | - | Santos Laguna [] | 2:1 | ||||
| 11. Round | 30/09/2023 | Santos Laguna [] | - | Mazatlán FC [] | 0:0 | ||||
| 13. Round | 14/10/2023 | Club Tijuana [] | - | Santos Laguna [] | 3:0 | ||||
| 15. Round | 28/10/2023 | Santos Laguna [] | - | UANL Tigres [] | 1:0 | ||||
| 16. Round | 04/11/2023 | CF Monterrey [] | - | Santos Laguna [] | 4:2 | ||||
| 17. Round | 11/11/2023 | Deportivo Guadalajara [] | - | Santos Laguna [] | 3:0 | ||||
| 18. Round | 18/11/2023 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:3 |
Mexico