| Preliminary | 08/03/2022 | Sol de América | - | General Caballero DJLM | 0:3 | ||||
| Group G | 06/04/2022 | General Caballero DJLM | - | Deportivo La Guaira | 1:1 | ||||
| Group G | 13/04/2022 | Independiente | - | General Caballero DJLM | 2:0 | ||||
| Group G | 26/04/2022 | General Caballero DJLM | - | Ceará - CE | 0:2 |  |
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| Group G | 26/05/2022 | Deportivo La Guaira | - | General Caballero DJLM | 0:1 |
Paraguay