| 4. Round | 22/07/2022 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 5:0 | ||||
| 5. Round | 26/07/2022 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:2 | ||||
| 6. Round | 30/07/2022 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:3 |  |
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| 7. Round | 07/08/2022 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 2:2 | ||||
| 8. Round | 11/08/2022 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 0:3 | |
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| 9. Round | 18/08/2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 0:2 | ||||
| 10. Round | 21/08/2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 5:0 | ||||
| 11. Round | 28/08/2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 | ||||
| 12. Round | 01/09/2022 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:2 | |
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| 15. Round | 18/09/2022 | Atlético San Luis [U20] | - | CF Pachuca [U20] | 1:3 | |
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| 17. Round | 01/10/2022 | Atlético San Luis [U20] | - | UANL Tigres [U20] | 2:2 |
Mexico