| Preliminary | 09/03/2022 | Cienciano | - | FBC Melgar | 1:1 | ||||
| Preliminary | 16/03/2022 | FBC Melgar | - | Cienciano | 1:0 | ||||
| Group B | 07/04/2022 | Cuiabá - MT | - | FBC Melgar | 2:0 | ||||
| Group B | 13/04/2022 | FBC Melgar | - | River Plate | 2:0 | ||||
| Group B | 27/04/2022 | FBC Melgar | - | Racing Club | 3:1 |  |
|||
| Group B | 03/05/2022 | River Plate | - | FBC Melgar | 1:2 | ||||
| Group B | 19/05/2022 | Racing Club | - | FBC Melgar | 1:0 | ||||
| Group B | 26/05/2022 | FBC Melgar | - | Cuiabá - MT | 3:1 | ||||
| Round of 16 | 30/06/2022 | Deportivo Cali | - | FBC Melgar | 0:0 | ||||
| Round of 16 | 07/07/2022 | FBC Melgar | - | Deportivo Cali | 2:1 | ||||
| Quarter-finals | 04/08/2022 | FBC Melgar | - | Internacional | 0:0 | ||||
| Quarter-finals | 11/08/2022 | Internacional | - | FBC Melgar | 1:3 pso | ||||
| Semi-finals | 01/09/2022 | Independiente del Valle | - | FBC Melgar | 3:0 | ||||
| Semi-finals | 08/09/2022 | FBC Melgar | - | Independiente del Valle | 0:3 |
Peru