| 1. Round | 02/07/2022 | UANL Tigres [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 2. Round | 09/07/2022 | Cruz Azul [U20] | - | CF Pachuca [U20] | 0:2 | ||||
| 3. Round | 16/07/2022 | Atlas Guadalajara [U20] | - | Cruz Azul [U20] | 2:0 | ||||
| 4. Round | 23/07/2022 | Cruz Azul [U20] | - | Puebla FC [U20] | 0:0 | ||||
| 5. Round | 26/07/2022 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:2 | ||||
| 6. Round | 30/07/2022 | Cruz Azul [U20] | - | Club Necaxa [U20] | 2:0 | ||||
| 7. Round | 06/08/2022 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:1 |  |
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| 8. Round | 13/08/2022 | Cruz Azul [U20] | - | Deportivo Toluca [U20] | 1:0 | |
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| 9. Round | 17/08/2022 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 | ||||
| 10. Round | 20/08/2022 | CF América [U20] | - | Cruz Azul [U20] | 2:0 | ||||
| 11. Round | 27/08/2022 | Cruz Azul [U20] | - | Gallos Blancos [U20] | 3:1 |  |
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| 12. Round | 02/09/2022 | FC Juárez [U20] | - | Cruz Azul [U20] | 0:3 | |
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| 13. Round | 06/09/2022 | CF Monterrey [U20] | - | Cruz Azul [U20] | 4:2 | ||||
| 14. Round | 11/09/2022 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:2 | ||||
| 16. Round | 15/09/2022 | Cruz Azul [U20] | - | Club León [U20] | 1:1 | |
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| 17. Round | 01/10/2022 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 1:1 |
Mexico